Bacteriophage-Induced Modifications of Host RNA Polymerase

Sergei Nechaev, Konstantin Severinov

Research output: Contribution to journalReview articlepeer-review

56 Citations (Scopus)


Bacteriophages have developed an impressive array of ingenious mechanisms to modify bacterial host RNA polymerase to make it serve viral needs. In this review we summarize the current knowledge about two types of host RNA polymerase modifications induced by double-stranded DNA phages: covalent modifications and modifications through RNA polymerase-binding proteins. We interpret the biochemical and genetic data within the framework of a structure-function model of bacterial RNA polymerase and viral biology.

Original languageEnglish
Pages (from-to)301-322
Number of pages22
JournalAnnual Review of Microbiology
Publication statusPublished - 2003
Externally publishedYes


  • Host transcription shut-off
  • Transcription regulation
  • Viral development


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