B cells, plasma cells and antibody repertoires in the tumour microenvironment

George V. Sharonov, Ekaterina O. Serebrovskaya, Diana V. Yuzhakova, Olga V. Britanova, Dmitriy M. Chudakov

    Research output: Contribution to journalReview articlepeer-review

    170 Citations (Scopus)

    Abstract

    Recent data show that B cells and plasma cells located in tumours or in tumour-draining lymph nodes can have important roles in shaping antitumour immune responses. In tumour-associated tertiary lymphoid structures, T cells and B cells interact and undergo cooperative selection, specialization and clonal expansion. Importantly, B cells can present cognate tumour-derived antigens to T cells, with the functional consequences of such interactions being shaped by the B cell phenotype. Furthermore, the isotype and specificity of the antibodies produced by plasma cells can drive distinct immune responses. Here we summarize our current knowledge of the roles of B cells and antibodies in the tumour microenvironment. Moreover, we discuss the potential of using immunoglobulin repertoires as a source of tumour-specific receptors for immunotherapy or as biomarkers to predict the efficacy of immunotherapeutic interventions.

    Original languageEnglish
    Pages (from-to)294-307
    Number of pages14
    JournalNature Reviews Immunology
    Volume20
    Issue number5
    DOIs
    Publication statusPublished - 1 May 2020

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