Autowave mechanisms of electrocardiographic variability during high-frequency arrhythmias: A study by mathematical modeling

A. B. Medvinsky, A. V. Rusakov, A. V. Moskalenko, M. V. Fedorov, A. V. Panfilov

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

High-frequency cardiac arrhythmias pose a high risk of sudden death. Their usual cause is the emergence of rotating autowaves. The Aliev-Panfilov model was used (i) to describe the dynamics of a rotating three-dimensional scroll-shaped excitation wave in homogeneous and heterogeneous media and (ii) to relate its dynamics to the results of normalized variability analysis (our variant of rescaled range analysis for electrocardiography; Moskalenko et al., Biofizika, 2001, vol. 46, no. 2, pp. 319-329) of model electrocardiograms obtained by summing local membrane potentials. In a homogeneous medium, the stability of a scroll wave against filament shape change was shown to depend on the excitability of the medium and on the filament tension. Scroll waves arising in inhomogeneous media were usually unstable. The dynamics of a three-dimensional scroll-shaped excitation wave was significantly related to the variability indices of model electrocardiograms. Higher excitation thresholds of the medium corresponded to larger variability indices. It was also found that at certain parameters the indices of electrocardiographic variability were larger in the homogeneous than in the inhomogeneous medium.

Original languageEnglish
Pages (from-to)297-305
Number of pages9
JournalBiophysics (Russian Federation)
Volume48
Issue number2
Publication statusPublished - 2003
Externally publishedYes

Keywords

  • Autowaves
  • Electrocardiographic variability
  • High-frequency arrhythmias
  • Mathematical modeling

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