Austalides V and W, new meroterpenoids from the fungus Aspergillus ustus and their antitumor activities

Tatiana V. Antipova, Kirill V. Zaitsev, Yuri F. Oprunenko, Alexander Ya. Zherebker, Gleb K. Rystsov, Marina Y. Zemskova, Valentina P. Zhelifonova, Natalya E. Ivanushkina, Anatoly G. Kozlovsky

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    Two new austalide meroterpenoids, named austalides V and W (1 and 2), were isolated from the fungus Aspergillus ustus VKM F-4692. Their structures were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. The main structural feature of both compounds is a tetrahydrofuranyl ring (G), a structural fragment, first found in austalides. Austalides V (1) and W (2) were able to inhibit the propagation of prostate and bladder cancer cells; this biologic activity is possibly related to the inhibition of a number of key pathways regulating cell growth and migration.

    Original languageEnglish
    Article number126708
    JournalBioorganic and Medicinal Chemistry Letters
    Volume29
    Issue number22
    DOIs
    Publication statusPublished - 15 Nov 2019

    Keywords

    • AKT-mTORC1 signaling pathway
    • Aspergillus ustus
    • Austalide
    • Fungus
    • Prostate and bladder cancer cells

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