Arginylation of β-actin regulates actin cytoskeleton and cell motility

Marina Karakozova, Marina Kozak, Catherine C.L. Wong, Aaron O. Bailey, John R. Yates, Alexander Mogilner, Henry Zebroski, Anna Kashina

Research output: Contribution to journalArticlepeer-review

195 Citations (Scopus)

Abstract

Posttranslational arginylation is critical for mouse embryogenesis, cardiovascular development, and angiogenesis, but its molecular effects and the identity of proteins arginylated in vivo are unknown. We found that β-actin was arginylated in vivo to regulate actin filament properties, β-actin localization, and lamella formation in motile cells. Arginylation of β-actin apparently represents a critical step in the actin N-terminal processing needed for actin functioning in vivo. Thus, posttranslational arginylation of a single protein target can regulate its intracellular function, inducing global changes on the cellular level, and may contribute to cardiovascular development and angiogenesis.

Original languageEnglish
Pages (from-to)192-196
Number of pages5
JournalScience
Volume313
Issue number5784
DOIs
Publication statusPublished - 14 Jul 2006
Externally publishedYes

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