Application of reporter strains for screening of new antibiotics

P. V. Sergiev, I. A. Osterman, A. Ya Golovina, E. S. Andreyanova, I. G. Laptev, P. I. Pletnev, S. A. Evfratov, E. I. Marusich, S. V. Leonov, Ya A. Ivanenkov, A. A. Bogdanov, O. A. Dontsova

Research output: Contribution to journalArticlepeer-review

Abstract

Screening for new antibiotics remains an important area of biology and medicine. Elucidation of the antibiotic mechanism of action is an indispensable part for this type of research. Preferentially, it should be carried out quickly and cost-effectively, on the stage of primary screening. In this review we describe application of reporter strains for rapid classification of antibiotics by their mechanisms of action, without prior purification of active compounds and determination of their chemical structure.

Original languageEnglish
Pages (from-to)293-299
Number of pages7
JournalBiochemistry (Moscow) Supplement Series B: Biomedical Chemistry
Volume10
Issue number4
DOIs
Publication statusPublished - 1 Oct 2016
Externally publishedYes

Keywords

  • antibiotic
  • bacteria
  • protein synthesis
  • reporter strain
  • screening

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