Application of reporter strains for new antibiotic screening

P. V. Sergiev, I. A. Osterman, A. Ya Golovina, I. G. Laptev, P. I. Pletnev, S. A. Evfratov, E. I. Marusich, S. V. Leonov, Ya A. Ivanenkov, A. A. Bogdanov, O. A. Dontsova

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

Screening for new antibiotics remains an important area of biology and medical science. Indispensable for this type of research is early identification of antibiotic mechanism of action. Preferentially, it should be studied quickly and cost-effectively, on the stage of primary screening. In this review we describe an application of reporter strains for rapid classification of antibiotics by its target, without prior purification of an active compound and determination of chemical structure.

Original languageEnglish
Pages (from-to)117-123
Number of pages7
JournalBiomeditsinskaya Khimiya
Volume62
Issue number2
DOIs
Publication statusPublished - 2016
Externally publishedYes

Keywords

  • Antibiotic
  • Bacteria
  • Protein synthesis
  • Reporter strain
  • Screening

Fingerprint

Dive into the research topics of 'Application of reporter strains for new antibiotic screening'. Together they form a unique fingerprint.

Cite this