Application of reporter strains for new antibiotic screening

P. V. Sergiev, I. A. Osterman, A. Ya Golovina, I. G. Laptev, P. I. Pletnev, S. A. Evfratov, E. I. Marusich, S. V. Leonov, Ya A. Ivanenkov, A. A. Bogdanov, O. A. Dontsova

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)


Screening for new antibiotics remains an important area of biology and medical science. Indispensable for this type of research is early identification of antibiotic mechanism of action. Preferentially, it should be studied quickly and cost-effectively, on the stage of primary screening. In this review we describe an application of reporter strains for rapid classification of antibiotics by its target, without prior purification of an active compound and determination of chemical structure.

Original languageEnglish
Pages (from-to)117-123
Number of pages7
JournalBiomeditsinskaya Khimiya
Issue number2
Publication statusPublished - 2016
Externally publishedYes


  • Antibiotic
  • Bacteria
  • Protein synthesis
  • Reporter strain
  • Screening


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