Anti-amyloid activities of three different types of water-soluble fullerene derivatives

Alexander G. Bobylev, Olga A. Kraevaya, Liya G. Bobyleva, Ekaterina A. Khakina, Roman S. Fadeev, Alexander V. Zhilenkov, Denis V. Mishchenko, Nikita V. Penkov, Ilia Y. Teplov, Elmira I. Yakupova, Ivan M. Vikhlyantsev, Pavel A. Troshin

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Anti-amyloid activity, aggregation behaviour, cytotoxicity and acute toxicity were investigated for three water-soluble fullerene derivatives with different types of solubilizing addends. All investigated compounds showed a strong anti-amyloid effect in vitrocaused by interaction of the water-soluble fullerene derivatives with the Ab(1-42)-peptide and followed by destruction of the amyloid fibrils. Notably, all of the studied fullerene derivatives showed very low cytotoxicity and low acute toxicity in mice (most promising compound 3 was more than four times less toxic than aspirin). Strong anti-amyloid effect of the fullerene derivatives together with low toxicity reveals high potential of these compounds as drug candidates for treatment of neurodegenerative diseases.

Original languageEnglish
Article number110426
JournalColloids and Surfaces B: Biointerfaces
Volume183
DOIs
Publication statusPublished - 1 Nov 2019

Keywords

  • Anti-amyloid activity
  • Fullerene derivatives

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