Amino acid residues required for maturation, cell uptake, and processing of translation inhibitor microcin C

Teymur Kazakov, Anastasia Metlitskaya, Konstantin Severinov

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Microcin C (McC), a peptide-nncleotide Trojan horse antibiotic, targets aspartyl-tRNA synthetase. We present the results of a systematic mutational study of the 7-amino-acid ribosomally synthesized peptide moiety of McC. Our results define amino acid positions important for McC maturation and cell uptake and processing and open the way for creation of more potent McC-based inhibitors.

Original languageEnglish
Pages (from-to)2114-2118
Number of pages5
JournalJournal of Bacteriology
Volume189
Issue number5
DOIs
Publication statusPublished - Mar 2007
Externally publishedYes

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