Air-filled microbubbles based on albumin functionalized with gold nanocages and zinc phthalocyanine for multimodal imaging

Elizaveta A. Maksimova, Roman A. Barmin, Polina G. Rudakovskaya, Olga A. Sindeeva, Ekaterina S. Prikhozhdenko, Alexey M. Yashchenok, Boris N. Khlebtsov, Alexander A. Solovev, Gaoshan Huang, Yongfeng Mei, Krishna Kanti Dey, Dmitry A. Gorin

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Microbubbles are intravascular contrast agents clinically used in diagnostic sonography, echocardiography, and radiology imaging applications. However, up to date, the idea of creating microbubbles with multiple functionalities (e.g., multimodal imaging, photodynamic therapy) remained a challenge. One possible solution is the modification of bubble shells by introducing specific compounds responsible for such functions. In the present work, air-core microbubbles with the shell consisting of bovine serum albumin, albumin-coated gold nanocages, and zinc phthalocyanine were prepared using the sonication method. Various physicochemical parameters such as stability over time, size, and concentration were investigated to prove the potential use of these microbubbles as contrast agents. This work shows that hybrid microbubbles have all the necessary properties for multimodal imaging (ultrasound, raster-scanning microscopy, and fluorescence tomography), which demonstrate superior characteristics for potential theranostic and related biomedical applications.

Original languageEnglish
Article number1161
JournalMicromachines
Volume12
Issue number10
DOIs
Publication statusPublished - Oct 2021

Keywords

  • Bovine serum albumin
  • Fluorescence tomography
  • Gold nanocages
  • Microbubbles
  • Multimodal imaging
  • Optoacoustic imaging
  • Ultrasound imaging
  • Zinc phthalocyanine

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