Adaptive silver films for surface-enhanced Raman spectroscopy of biomolecules

Vladimir P. Drachev, Mark D. Thoreson, Vishal Nashine, Eldar N. Khaliullin, Dor Ben-Amotz, V. Jo Davisson, Vladimir M. Shalaev

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)


The interaction of biological molecules with a typical substrate for surface-enhanced Raman scattering (SERS) often leads to their structural and functional changes. In this paper we describe SERS substrates, called adaptive silver films (ASFs), in which the biomaterial and the substrate act in concert to produce excellent Raman enhancement through local restructuring of the metal surface while at the same time preserving the properties (such as conformational state and binding activity) of the analyte. These adaptive substrates show great promise for SERS spectroscopy of many different types of biomolecules, and we provide several current examples of their use.

Original languageEnglish
Pages (from-to)648-656
Number of pages9
JournalJournal of Raman Spectroscopy
Issue number6-7
Publication statusPublished - Jun 2005
Externally publishedYes


  • Insulin
  • Metal nanostructures
  • Protein binding reaction
  • Protein sensing
  • Surface-enhanced Raman scattering


Dive into the research topics of 'Adaptive silver films for surface-enhanced Raman spectroscopy of biomolecules'. Together they form a unique fingerprint.

Cite this