Adaptive silver films for bio-array applications

Vladimir P. Drachev, Vishal Nashine, Mark D. Thoreson, Eldar N. Khaliullin, Dor Ben-Amotz, V. Jo Davisson, Vladimir M. Shalaev

Research output: Contribution to journalConference articlepeer-review

1 Citation (Scopus)


The adaptive property of e-beam evaporated silver films was investigated and employed for protein sensing with surface-enhanced Raman scattering (SERS). The approach for sensing proteins was based on adaptive silver films (ASF). It was demonstrated that adaptive nanostructured films can be used for the observation of differences in SERS spectra of recombinant human insulin and insulin lispro at sub-monolayer protein surface densities and provide macroscopic enhancement factor of about 3×10 6. The stabilization and the restructuring of the ASFs by the proteins was also presented.

Original languageEnglish
Article numberTuDD4
Number of pages1
JournalConference Proceedings - Lasers and Electro-Optics Society Annual Meeting-LEOS
Publication statusPublished - 2004
Externally publishedYes
Event2004 IEEE LEOS Annual Meeting Conference Proceedings, LEOS 2004 - Rio Grande, Puerto Rico
Duration: 7 Nov 200411 Nov 2004


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