Knockout (KO) models have provided important insights into the function of many receptors and signalling molecules. However, analysis of endothelin (ET) receptor knockouts has been complicated by the development of lethal phenotypes. In this paper, we present our strategy for examining endothelin-B- (ET(B)) receptor function in the context of other strategies for rescuing the lethal phenotype of ET(B) knockout mice.
|Journal||Journal of Cardiovascular Pharmacology|
|Issue number||5 SUPPL. 1|
|Publication status||Published - 2000|
- Cre recombinase
- Endothelin (ET)
- Knockout (KO)