A transgenic strategy for analysis of the function of the endothelin-B-receptor

A. Bagnall, D. Webb, Y. Kotelevtsev

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Knockout (KO) models have provided important insights into the function of many receptors and signalling molecules. However, analysis of endothelin (ET) receptor knockouts has been complicated by the development of lethal phenotypes. In this paper, we present our strategy for examining endothelin-B- (ET(B)) receptor function in the context of other strategies for rescuing the lethal phenotype of ET(B) knockout mice.

Original languageEnglish
Pages (from-to)S90-S92
JournalJournal of Cardiovascular Pharmacology
Issue number5 SUPPL. 1
Publication statusPublished - 2000
Externally publishedYes


  • Cre recombinase
  • Endothelin (ET)
  • ET(B)-receptor
  • Knockout (KO)
  • Transgenic


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