A structural perspective of compensatory evolution

Dmitry N. Ivankov, Alexei V. Finkelstein, Fyodor A. Kondrashov

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)


The study of molecular evolution is important because it reveals how protein functions emerge and evolve. Recently, several types of studies indicated that substitutions in molecular evolution occur in a compensatory manner, whereby the occurrence of a substitution depends on the amino acid residues at other sites. However, a molecular or structural basis behind the compensation often remains obscure. Here, we review studies on the interface of structural biology and molecular evolution that revealed novel aspects of compensatory evolution. In many cases structural studies benefit from evolutionary data while structural data often add a functional dimension to the study of molecular evolution.

Original languageEnglish
Pages (from-to)104-112
Number of pages9
JournalCurrent Opinion in Structural Biology
Issue number1
Publication statusPublished - Jun 2014
Externally publishedYes


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