A non-bacterial transcription factor inhibits bacterial transcription by a multipronged mechanism

Carol Sheppard, Ellen James, Geraint Barton, Stephen Matthews, Konstantin Severinov, Sivaramesh Wigneshweraraj

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)

Abstract

The process of transcription initiation is the major target for regulation of gene expression in bacteria and is performed by a multi-subunit RNA polymerase enzyme (RNAp). A complex network of regulatory elements controls the activity of the RNAp to fine-tune transcriptional output. Thus, RNAp is a nexus for controlling bacterial gene expression at the transcription level. Many bacteriophages, viruses that infect bacteria, encode transcription factors that specifically target and modulate the activity of the host RNAp and, thereby, facilitate the acquisition of the host bacteria by the phage. Here, we describe the modus operandi of a T7 bacteriophage-encoded small protein called Gp2 and define Gp2 as a non-bacterial regulator of bacterial transcription.

Original languageEnglish
Pages (from-to)495-501
Number of pages7
JournalRNA Biology
Volume10
Issue number4
DOIs
Publication statusPublished - Apr 2013
Externally publishedYes

Keywords

  • Bacterial transcription regulation
  • Bacteriophage
  • Gp2
  • RNA polymerase
  • T7 inhibition
  • σ factor

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