A new technique for unbiased external ion accumulation in a quadrupole two-dimensional ion trap for electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry

Mikhail E. Belov, Evgenii N. Nikolaev, Kim Alving, Richard D. Smith

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

External ion accumulation in a two-dimensional (2D) multipole trap has been shown to increase the sensitivity, dynamic range and duty cycle of a Fourier transform ion cyclotron resonance (FTICR) mass spectrometer. However, it is important that trapped ions be detected without significant bias at longer accumulation times in the external 2D multipole trap. With increasing ion accumulation time pronounced m/z discrimination was observed when trapping ions in an accumulation quadrupole. In this work we show that superimposing lower rf-amplitude dipolar excitation over the main rf-field in the accumulation quadrupole results in disruption of the m/z discrimination and can potentially be used to achieve unbiased external ion accumulation with FTICR.

Original languageEnglish
Pages (from-to)1172-1180
Number of pages9
JournalRapid Communications in Mass Spectrometry
Volume15
Issue number14
DOIs
Publication statusPublished - 2001
Externally publishedYes

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