A new approach to the synthesis of ligands of asialoglycoprotein receptor for targeted delivery of oligonucleotides to hepatocytes

S. Yu Maklakova, F. A. Kucherov, R. A. Petrov, V. V. Gopko, G. A. Shipulin, T. S. Zatsepin, E. K. Beloglazkina, N. V. Zyk, A. G. Majouga, V. E. Koteliansky

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    A new approach to the synthesis of organic ligands of asialoglycoprotein receptor was suggested. It was shown that the azido-containing tervalent N-acetylglucosamine and N-acetylmannosamine derivatives obtained by this method can serve as convenient starting compounds for the synthesis of therapeutical conjugates with oligonucleotides containing a terminal alkyne.

    Original languageEnglish
    Pages (from-to)1655-1662
    Number of pages8
    JournalRussian Chemical Bulletin
    Volume64
    Issue number7
    DOIs
    Publication statusPublished - 1 Jul 2015

    Keywords

    • Asialoglycoprotein receptor
    • Azide-alkyne cycloaddition
    • Hepatocytes
    • Ligand
    • Oligonucleotide

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