A hierarchy in clusters of cephalopod mRNA editing sites

Mikhail A. Moldovan, Zoe S. Chervontseva, Daria S. Nogina, Mikhail S. Gelfand

Research output: Contribution to journalArticlepeer-review


RNA editing in the form of substituting adenine with inosine (A-to-I editing) is the most frequent type of RNA editing in many metazoan species. In most species, A-to-I editing sites tend to form clusters and editing at clustered sites depends on editing of the adjacent sites. Although functionally important in some specific cases, A-to-I editing usually is rare. The exception occurs in soft-bodied coleoid cephalopods, where tens of thousands of potentially important A-to-I editing sites have been identified, making coleoids an ideal model for studying of properties and evolution of A-to-I editing sites. Here, we apply several diverse techniques to demonstrate a strong tendency of coleoid RNA editing sites to cluster along the transcript. We show that clustering of editing sites and correlated editing substantially contribute to the transcriptome diversity that arises due to extensive RNA editing. Moreover, we identify three distinct types of editing site clusters, varying in size, and describe RNA structural features and mechanisms likely underlying formation of these clusters. In particular, these observations may explain sequence conservation at large distances around editing sites and the observed dependency of editing on mutations in the vicinity of editing sites.

Original languageEnglish
Pages (from-to)3447
Number of pages1
JournalScientific Reports
Issue number1
Publication statusPublished - 2 Mar 2022


Dive into the research topics of 'A hierarchy in clusters of cephalopod mRNA editing sites'. Together they form a unique fingerprint.

Cite this