2'-Hydrazine oligonucleotides: synthesis and efficient conjugation with aldehydes.

Timofei S. Zatsepin, Dmitry A. Stetsenko, Michael J. Gait, Tatiana S. Oretskaya

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Oligodeoxyribonucleotides that contain a novel nucleoside, 2'-O-(2-hydrazinoethyl)uridine, were synthesized by sodium cyanoborohydride reduction of hydrazones formed from 2'-aldehyde oligonucleotides and FmocNHNH2 followed by ammonia deprotection. 2'-Hydrazine oligonucleotides were used successfully to obtain a series of conjugates with various aldehydes by hydrazone formation. The method was shown to be suitable for the preparation of oligonucleotide-peptide conjugates.

Original languageEnglish
Pages (from-to)133-134
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number49
DOIs
Publication statusPublished - 2005
Externally publishedYes

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