2′-Functionalized nucleic acids as structural tools in molecular biology

Timofei S. Zatsepin, Michael J. Gait, Tatiana S. Oretskaya

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)


Modified oligonucleotides bearing 2′-reactive groups or 2′-conjugated molecules have found wide application as structural tools in molecular biology. Of principal interest has been the use of 2′-reactive oligonucleotides for cross-linking with biomolecules and of 2′-conjugated oligonucleotides in hybridization assays. In this review we compare a range of electrophilic, nucleophilic and photoreactive groups for cross-linking and conjugation studies.

Original languageEnglish
Pages (from-to)209-214
Number of pages6
JournalIUBMB Life
Issue number4
Publication statusPublished - Apr 2004
Externally publishedYes


  • Cross-linking
  • Fluorescent probes
  • Modified oligonucleotide
  • Reactive group
  • Structure of nucleic acids


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