Митохондриальная ДНК как фактор развития глаукомной оптической нейропатии

Translated title of the contribution: Mitochondrial DNA as a factor of glaucomous optic neuropathy’s development mechanism

I. R. Gazizova, I. O. Mazunin, T. N. Malishevskaya, O. A. Kiseleva, A. M. Gadzhiev, Al M. Rindzhibal

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Currently, the mitochondrial component is becoming increasingly significant in the development and progression of glaucoma optic neuropathy. Since mitochondria have their own genetic apparatus, the study of qualitative and quantitative changes in mitochondrial DNA (mtDNA) becomes part of the disease diagnosis, in addition to studying the functional characteristics of the organelles alone. Moreover, the inability to explain the nature of the disease by known mutations of nuclear DNA contributes to the the study of mtDNA. In this review, we briefly discuss the mitochondrial genetics and the role of mitochondrial haplogroups in the diseases manifestation. We summarize the accumulated data on the qualitative and quantitative changes in mtDNA in patients with glaucoma. We discuss the approach to prevent the inheritance of mutant mtDNA as a part of assisted reproductive technologies, as well as the first steps towards the mtDNA heteroplasmy level manipulation and direct mtDNA editing.

Translated title of the contributionMitochondrial DNA as a factor of glaucomous optic neuropathy’s development mechanism
Original languageRussian
Pages (from-to)479-486
Number of pages8
JournalOftalmologiya
Volume16
Issue number4
DOIs
Publication statusPublished - 2019
Externally publishedYes

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