Исследование протеома мочи у пациентов с постинфарктным кардиосклерозом и артериальной гипертензией для оценки дисфункции эндотелия

Translated title of the contribution: Analysis of urine proteome in patients with postinfarction cardiosclerosis combined with hypertensive disease for assessing endothelial dysfunction

L. Kh Pastushkova, D. N. Kashirina, I. V. Dobrokhotov, A. S. Kononikhin, E. S. Tiys, V. A. Ivanisenko, O. M. Veselova, O. N. Vyborov, A. M. Nosovskiy, V. P. Masenko, I. N. Goncharov, E. N. Nikolaev, I. M. Larina

Research output: Contribution to journalArticlepeer-review

Abstract

In our study urine protein composition of 18 healthy volunteers was compared with that of 18 patients with ischemic heart disease and concomitant hypertension. Liquid chromatography-mass-spectrometry (LC-MS) analysis of the second fraction of morning urine was carried out using nano-line high performance liquid chromatograph and hybrid mass spectrometer. The analysis revealed 23 proteins expressed in the endothelium, according to the information contained in the database Bgee, and 49 proteins, with direct functional link with the processes in the endothelium in the reconstruction of associative networks using ANDSystem program. Comparison of urine proteome of healthy people and patients with postinfarction cardiosclerosis revealed proteins specific for patients with cardiovascular disease. Thus, proteins vitronectin, syndecan-4, a histidine rich glycoprotein, endothelial protein C receptor, colony stimulating factor, cathepsin D and sekretogranin-1 may be considered as potential markers for cardiovascular diseases. Further research in this area should be conducted for clinical and experimental verification of these hypotheses.

Translated title of the contributionAnalysis of urine proteome in patients with postinfarction cardiosclerosis combined with hypertensive disease for assessing endothelial dysfunction
Original languageRussian
Pages (from-to)49-58
Number of pages10
JournalKardiologiya
Volume57
Issue number11
DOIs
Publication statusPublished - 2017
Externally publishedYes

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