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20082022

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Research interests

Dr. Ekaterina Khrameeva graduated from the Department of Bioengineering and Bioinformatics, Moscow State University, in 2009. Since 2007, she has been working with Prof. Mikhail Gelfand at the Institute for Information Transmission Problems, where she defended her PhD thesis on chromatin architecture and alternative splicing, in 2015. During her postgraduate studies, Ekaterina worked as a bioinformatician at the Justus Liebig University (Giessen), the Helmholtz Zentrum München (Munich), the Partner Institute for Computational Biology (Shanghai), and the Leiden University Medical Center (Netherlands). Starting from 2014, she has been working on the analysis of lipidome and transcriptome in the human brain with Prof. Philipp Khaitovich at Skoltech. In 2019, Ekaterina has been promoted to the position of an Assistant Professor at the Center of Life Sciences. Ekaterina won several competitions and research grants and published 29 papers.

Academic Reputation and Societal Impact

Prof. Khrameeva is a specialist in deep bioinformatics analysis of various types of omics data, well-known both nationally and internationally. Being the key computational biologist in each of her projects, Prof. Khrameeva maintains collaborations with strong wet-lab groups producing the data, both in Russia and abroad.

Studies of the human brain lipidome and transcriptome
Massive changes in brain lipid concentrations were detected in cognitive diseases associated with impaired human brain functions, such as autism and schizophrenia. Besides, the implementation of cognitive processes such as social behavior, reaction to stress, and post-traumatic behavioral syndromes is associated with changes in lipidome. These observations, as well as the fact that lipids play a key role in all processes occurring in the brain, suggest that a brain lipidome can be a promising source of information about the functional activity of the brain. Our studies allow us to create an overall picture of the molecular organization of the human brain, which will make it possible, among other things, to identify key regions of the brain and functional aggregates of these regions that can serve as the object of further research aimed at studying cognitive abilities and brain-associated diseases in humans.

Chromatin 3D structure
Changes in gene expression associated with chromatin 3D structure changes lead to serious human diseases, and the study of these processes is necessary to develop new methods of treatment and diagnosis. Importantly, in this project, all the results will be obtained by computational biology methods, which is important from the economical point of view since computational biology methods are much cheaper than experimental methods.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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