Genomics Core Facility was established at Skoltech in March 2018. It contains high-throughput Illumina sequencers HiSeq4000 and MiniSeq, equipment for nucleic acid extraction, library preparation and quality control (Illumina cBot 2, Biomek NXp Span-8, Covaris M220, Bioanalyzer 2100 etc.) and computational resources for data storage and analysis. Genomics is one of the key areas of biological and biomedical research. The most modern and high-throughput genomics method is the next-generation sequencing (NGS). It allows determining sequences of many thousands of fragments without their physical separation (e.g. by cloning) and is therefore rapid and cost-effective. Development of NGS methods enabled characterization of the genomes of many species and individuals of the same species, detailed analysis of gene expression in different organs and developmental stages etc. This resulted in revolutionary advancements in many fields of science, including genetics, evolutionary biology, microbiology, anthropology. NGS is used not only in fundamental research but also in applied science, in particular, for the search of genetic basis of inherited diseases, for the analysis of the dynamics of microbial communities, the search of genes associated with economically important traits in plants and animals, and many others. The main goal of the Facility is to coordinate and support genomic research programs carried out by Skoltech researchers, participants of Skolkovo ecosystem as well as external customers.