Advanced Mass Spectrometry Core Facility (AMS) was established at Skoltech in March 2019. AMS is equipped with wide range of mass-spectrometers covering all needs in the field of proteomic and metabolomics studies. Currently AMS has five mass-spectrometers. Among them two Q-exactive (benchtop Hybrid Quadrupole-Orbitrap™ Mass Spectrometer coupled to conventional flow rate UPLC (Waters)). Three MSs from Bruker: "Impact" Q-TOF mass-spectrometer, TIMS-TOF (upgraded to "pro" in 2019) and "RapifleX" MALDI-TOF with the MALDI Imaging Option. Together with state of the art mass-spectrometric equipment, the sample preparation and bioinformatic support we are able to perform the whole experimental cycle for the research and industry. The main goal of AMS is to provide high quality service for Skoltech internal users as well as services to external partners.